Imaging for better decisions

Respiratory

Quantitative MRI and ventilation imaging to support respiratory drug development.

• Oxygen-enhanced MRI (OE-MRI) ventilation biomarkers
• DCE-MRI perfusion and microvascular measures
• Motion-based ventilation imaging without gases
• Support for hyperpolarised 129Xe studies
• Validated methods across vendors and sites

Oncology

Assess tumour hypoxia, perfusion, and therapy response with quantitative imaging.

• Oxygen-enhanced MRI (OE-MRI) for tumour hypoxia
• DCE-MRI biomarkers of angiogenesis and perfusion
• Diffusion MRI (ADC) for early response detection
• Cross-site protocol standardisation and QA
• Auditable analysis and reporting with VoxelFlow

Inflammation

Inflammation biomarkers for arthritis, autoimmune disease, and organ injury.

• DCE-MRI Ktrans biomarkers of microvascular function
• Joint imaging in rheumatoid arthritis and osteoarthritis
• Renal imaging biomarkers including ASL, T1, T2, ADC
• Hypoxia and pH imaging methods (BOLD, OE-MRI, CEST)
• Sensitive, repeatable measurements with small cohorts

Neuroimaging

Brain MRI biomarkers for neurodegeneration, neuro-oncology, and CNS trials.

• Atrophy and diffusion metrics for neurodegeneration
• DCE-MRI for subtle blood-brain barrier dysfunction
• Arterial spin labelling (ASL) perfusion methods
• MR spectroscopy and relaxometry
• AI stratification with Queen Square Analytics

Liver imaging

Non-invasive liver function assessment and fibrosis mapping with MRI.

• Gadoxetate DCE-MRI for uptake and efflux kinetics
• Relaxometry (T1, T2, T2*) for tissue status
• TRISTAN project leadership and validation
• FDA biomarker qualification program acceptance
• Study design, QC, analysis, and reporting

MR Spectroscopy

Metabolic profiling with MR spectroscopy to understand tissue chemistry.

Publications

Peer-reviewed evidence and case studies of imaging biomarker delivery.

Software Development Services

Custom software solutions to streamline imaging workflows and analytics.

Trial design

Trial design guidance and imaging strategies aligned with clinical endpoints.

VoxelFlow

VoxelFlow delivers compliant analytics and traceable biomarker reporting.

Imaging Data Management

Secure, scalable imaging data pipelines for multi-site trials.

Imaging Site Support

Site training, qualification, and support to reduce imaging variability.

MR Protocol development & harmonisation

MR protocol development, harmonisation, and cross-site consistency checks.

Quality & Compliance

Quality frameworks and compliance support across imaging programs.